Transfusion Medicine
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In organ transplantation and hematopoietic stem cell transplantation, the similarity between HLA antigens of the donor and recipient affects graft survival and transplant outcomes. HLA matching before transplant is an important laboratory testing for immunologic risk assessment. Antibodies directed against mismatched donor HLA antigens are associated with graft rejection. |
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HLA matching, Crossmatching and antibody testing
We performed complement-dependent cytotoxic crossmatch, HLA antibody testing and HLA typing for organ transplantation including kidney, liver and heart transplant and hematopoietic stem cell transplant. Our Lab are accredited by ISO15189 and participated in Asia-Pacific Histocompatibility and Immunogenetic Association (APHIA) proficiency program. We worked in collaboration with Ramathibodi Excellent Center for Organ Transplantation (visit the website https://med.mahidol.ac.th/ramatransplantcenter).
There are more than 2,000 kidney transplants and more than 200 liver transplants performed at Ramathibodi Hospital. One of the major problems after transplantation is chronic antibody-mediated rejection. Our current research focuses on donor-specific antibodies and the association with transplant outcomes. |
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Associate Professor Duangtawan Thammanichanond, MD. PhD.
Research: HLA antibody in organ transplantation, HLA epitope mismatch in organ and hematopoietic stem cell transplantation
Goal: To search for factors and specificity of HLA antibodies that related to clinical significance. My research also focuses on relevancies of HLA epitope mismatching in transplant outcomes.