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Pharmacogenomics and Personalized Medicine Laboratory

Pharmacogenomics and Personalized Medicine Laboratory

Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Pharmacogenomics and Personalized Medicine program focuses on teaching and learning about how human genetic abnormalities affect an individual's responses to different drugs. The most important aspect of Pharmacogenomics research is to increase patients’ quality of life by preventing the adverse drug reaction and adjusting the proper dose for each patient. We have 3 major parts in Pharmacogenomics laboratory: Genotype, Phenotype and Pharmacogenomics Clinic which we can create new knowledge in order to apply into clinical setting.
 
 
Genotype
We have 3 main research fields for genetic profiles including HLA gene, CYP450 profiles and other genes that involved in pharmacokinetics and pharmacodynamics. For example, HLA-B*1502 for carbamazepine treatment, CYP2B6 for Efavirenz treatment and TPMT/NUDT15 for ALL patients. We perform PCR-SSOP-luminex method and real-time PCR to detect the genetic risks of patients before starting a treatment. Our Laboratory testing are continuing to improve as we are accredited by ISO15189.

 

Phenotype

 

Enzyme activities, Pharmacokinetic and Individualized Dose adjustment are significant part in monitoring and fulfilling the understanding of human biological system with different genetic profiles. We use Liquid Chromatography-tandem mass spectrometry (LC-MS/MS) technique which is highly specific, sensitive and reliable method for enzyme activity quantitation and dose adjustment testing. For example, the TPMT activity in ALL patient and dose adjustment of busulfan.

 

 

 

Pharmacogenomics clinic

 

In this part, you will learn to take Pharmacogenomics knowledge into clinical practice in terms of drug efficacy, toxicity and safety. We work based on scientific paper and our current research. In addition, you can learn the integration of genetic factors and non-genetic factors such as ethnicity, lifestyle, environment that have an influence on a comprehensive review of patients’ manifestation.

 

Contact details:

 

For more information please contact us via the followings;

 

Pharmacogenomics and Personalized Medicine Laboratory,
Department of Pathology, Faculty of
Medicine Ramathibodi Hospital,
Mahidol University 270 Rama 6 Road,
Rachathewi, Bangkok, Thailand 10400

 

Tel. and Fax +6622011390, +6622004331
E-mail: apichaya.pua@mahidol.ac.th
 
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Associated Professor Chonlaphat Sukasem, Ph.D.
Research: Pharmacogenomics
Goal: Exploring new pharmacogenomics marker specifically for Thai population to prevention drug adverse effect and improve drug efficiency.
Current funds: -R
 
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Assistant Professor Apichaya Puangpetch, Ph.D.
Research: Pharmacogenomics of 6-mercaptopurine in Acute Lymphoblastic Leukemia Pharmacogenomics of Asthma Pharmacogenomics of anti-psychiatry
Goal: To investigate pharmacogenomics marker and apply the physiologically-based pharmacokinetic model (PBPK) to improve the patients’ treatment in terms of toxicity prevention and high-efficacy treatments.
Current funds: Ramathibodi Research Grant R