Outstanding project
Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes
Bactrim, A.K..A. Sulfamethoxazole Trimethoprim, is an antibiotic in the sulfa drug class. It is widely used as treatment for bacterial infections which reported as the no.1 in Thai’s most drug allergy. This drug is used as the disinfec...tant, according to the information from Ministry of Public Health (MOPH), providing effects on a wide range. Faculty of Medicine Ramathibodi Hospital has conducted a project called "Pharmacogenetics to the severe skin eruptions in Thai people" which aims to have a case-control study; particularly among Thai people, in order to find the risk, and the result of study will lead to develop the drug-allergy gene testing prior to give any medication, reducing the risk of drug allergies in several types of drugs.
As per the Pharmacogenetic Marker (PGx marker) to the Bactrim, A.K..A.Sulfamethoxazole Trimethoprim, intolerance to the HLA B * 15: 02 and the HLA C * 08: 01 are associated with the occurrence of drug allergy Stevens-Johnson's Syndrome; skin peeling, rashes, Allergic Conjunctivitis, and Mucositis, while the HLA B * 13: 01 abnormalities were associated with DRESS (Drug Reaction with Eosinophillia and Systemic Symptoms), which are in severity with the same mortality rate. On average, people with the abnormal gene are about 15 times more likely to have a drug allergy than those people without the abnormal gene. The study is the world's first discovery of genes in Thai people being allergic to “Bactrim” A.K..A. a group of antibiotics in the sulfa drugs, leading to the the drug-allergy gene testing prior to give any medication which will help reducing the risk of drug allergies.
This research was also published in the international journal, Clinical Pharmacology and Therapeutics; impact factors 7.266 (Q1) with JCR No. 16/270 (in the field of pharmacology and pharmacy). This new body of knowledge showing the world that the PGx marker of the severe allergic skin rash of Co-trimoxazole is specific to the drug allergy pattern. This study also received strong attention from the University of Liverpool to continue further study.
As per the Pharmacogenetic Marker (PGx marker) to the Bactrim, A.K..A.Sulfamethoxazole Trimethoprim, intolerance to the HLA B * 15: 02 and the HLA C * 08: 01 are associated with the occurrence of drug allergy Stevens-Johnson's Syndrome; skin peeling, rashes, Allergic Conjunctivitis, and Mucositis, while the HLA B * 13: 01 abnormalities were associated with DRESS (Drug Reaction with Eosinophillia and Systemic Symptoms), which are in severity with the same mortality rate. On average, people with the abnormal gene are about 15 times more likely to have a drug allergy than those people without the abnormal gene. The study is the world's first discovery of genes in Thai people being allergic to “Bactrim” A.K..A. a group of antibiotics in the sulfa drugs, leading to the the drug-allergy gene testing prior to give any medication which will help reducing the risk of drug allergies.
This research was also published in the international journal, Clinical Pharmacology and Therapeutics; impact factors 7.266 (Q1) with JCR No. 16/270 (in the field of pharmacology and pharmacy). This new body of knowledge showing the world that the PGx marker of the severe allergic skin rash of Co-trimoxazole is specific to the drug allergy pattern. This study also received strong attention from the University of Liverpool to continue further study.
SJS and TEN 2556-2560
DRESS 2556-2560
Saliva Sample Screening for SARS-CoV-2
The Faculty of Medicine Ramathibodi Hospital, Mahidol University, has conducted study on Saliva Sample as a Non-Invasive Specimen for the Diagnosis of Coronavirus Disease-2019 (COVID-19) that counted as the convenient sampling methods; less equipment required, additionally, it can be expanded for infec...tious screening at various locations. Moreover, The Faculty of Medicine Ramathibodi Hospital, along with the Faculty of Sciences, Mahidol University, and the Department of Medical Sciences, Ministry of Public Health, cooperated in study for the COVID-19 screening test kit, the new solution used LAMP PCR technology to test patients’ saliva. This test kit can produce a result of the COVID-19 detection rapidly within 1 hour. It is also accurate, cheaper, and safe for medical personnel working at site. This regards as a great achievements for Thai medical innovation, as well as a great benefit in controlling the Thailand’s COVID-19 situation.
