Succimer

 

  • Name of product: Succimer also called Dimercaptosuccinic acid (DMSA)

  • Dosage  form: Capsule (oral)

  • Strength:  200 mg

  • Pack size: 15 capsules

  • Manufacturer: Laboratories Serb (France)

Uses

  • lead poisoning

Contraindications

  • drug hypersensitivity

Precautions

  • renal impairment

Pregnancy category: C

Dose

  • ADULT: 10 mg/kg every 8 hours a day for 5 days, followed by 10 mg/kg twice daily for 14 days

  • CHILD: 350 mg/m2 every 8 hours a day for 5 days, followed by 350 mg/m2 twice daily for 14 days

Adverse drug reaction

  • Rash, Diarrhea, Loss of appetite, Nausea, Vomiting

Reference:

  • Kosnett MJ. Succimer (DMSA). In: Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, et al., editors. Poisoning & Drug Overdose. 7th ed. New York: McGraw-Hill Education; 2018. p. 624-6.
  • Howland MA. Succimer (2,3-Dimercaptosuccinic acid) and DMPS (2,3-Dimercapto-1-Propanesulfonic acid). In: Lewis S. Nelson, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, editors. Goldfrank’s Toxicologic Emergencies. 11th ed. New York: McGraw-Hill Education; 2019. p. 1309-14.
  • World Health Organization. WHO guideline for clinical management of exposure to lead [Internet]. 2021 [cited 2022 Jan 16]. Available from: https://www.who.int/publications/i/item/9789240036888.