Na me of product: Sodium thiosulfate  Dosage  form: Injection (i.v.) Strength:  250 mg/mL   Pack size: 5 x 18 mL vials Manufacturer: The Thai Red Cross Society (Thailand)

Uses

• cyanide poisoning (together with sodium nitrite); pityriasis versicolor.

Dose

• Cyanide poisoning, after administration of sodium nitrite, by slow intravenous injection over about 10 minutes (rate 2.5 - 5 mL/min)
  • ADULT, 12.5 g (50 mL of 25% sodium thiosulfate); further dose of 6.25 g after 30 minutes if symptoms recur
  • CHILD, 250 mg/kg (1.0 mL/kg)  or  30 - 40 mL/m² of BSA (maximum dose 12.5 g)

Adverse drug reaction

• Hypotension, Nausea, Vomiting and prolong bleeding time (1 - 3 day after a single IV infusion)

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Reference

• Ho RY. Thiosulfate, Sodium. In: Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, et al., editors. Poisoning & Drug Overdose. 7th ed. New York: McGraw-Hill Education; 2018. p.629-630.
• Howland MA. Nitrites (Amyl and Sodium) and Sodium Thiosulfate. In: Lewis S. Nelson, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS, editors. Goldfrank’s Toxicologic Emergencies. 11th ed. New York: McGraw-Hill Education; 2019. p.1698 - 1702.